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This reflects its relationship with NNMT and cellular metabolic pathways

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The earliest equation to explain the rate of dissolution when the process is diffusion controlled and involves no chemical reaction was given by Noyes and Whitney: where, dC/dt = dissolution rate of the drug, k = dissolution rate constant (first order), Cs = concentration of drug in the stagnant layer (also called as the saturation or maximum drug solubility), and Cb = concentration of drug in the bulk of the solution at time t