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Keywords: Hidradenitis suppurativa, interleukin-1 receptor-associated kinase 4, IL-1R/TLR signalling pathway, cytokines Introduction IRAK4, a serine/threonine kinase in the IRAK family, is characterized by a conserved N-terminal death domain (DD) and a central kinase domain (KD)

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In addition to RIDD, IRE1α also induces non-conventional splicing and activation of XBP1, a major transcription factor regulating ER homeostasis 10,66,67,68,69