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Currently, genetic deficiencies have been reported for five of the enzymes in the cycle: γ-glutamylcysteine synthetase, GSS, γ-glutamyl transpeptidase, 5-oxoprolinase, and dipeptidase (Figure 1)

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The most recent preclinical efficacy study, Babula, Bui, Stevenson, and colleagues, published in Diabetes, Obesity and Metabolism in 2024, confirmed that NNMT inhibition mitigates obesity-related metabolic dysfunction in preclinical models