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Ferritin levels indicate iron reserves, deficiency, and overload and should be determined before initiating Fe supplementation to mitigate the risk and damage associated with iron overload

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Activating SIRT1 upregulates AMPK, inhibits mTOR phosphorylation and induces autophagy, thereby sensitizing EML4-ALK mutant cells (L1196M, G1202R) to crizotinib (137)