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Ascorbic acid can also directly enhance the catalytic activity of Tet methylcytosine dioxygenase 2 (TET2) in the oxidation of 5-methylcytosine (5mC), promote the folding and/or recycling of the cofactor Fe (2 + ) for TET2, and improve symptoms of depression (Ma et al., 2024

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Nov 13 2017;24(1):84