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It is a partial sequence derived from a protein found in human gastric juice, which is one reason much of its early research focused on the gastrointestinal tract

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Taken together, this study found that at a 3 week timepoint, cuprizone pellets were more efficacious than cuprizone powder at producing astrocyte reactivity, microglial activation, oxidative stress, tissue swelling, and a reduction in the density of mature oligodendrocytes and demyelination when compared to control feeds, particularly in the caudal corpus callosum

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