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SGLT2 inhibitors attenuate oxidative stress through multifaceted mechanisms encompassing glucotoxicity reduction and mitochondrial functional enhancement (308)

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4.4 PPARs and NF-κB signaling pathways PPARs are ligand-activated transcription factors belonging to the nuclear hormone receptor superfamily and are key regulators of various pathophysiological processes related to energy metabolism, including lipid, carbohydrate metabolism, and inflammation