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6.3 T-bet and Ferroptosis-related signaling pathway Ferroptosis represents a regulated mechanism of cellular demise, distinguished by the iron-dependent accumulation of lipid peroxidation to cytotoxic levels

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Studies have suggested that in response to cisplatin, cancer cells deficient in BRCA , a gene involved in HR, show significantly more chromosomal abnormalities than wild type (WT) cells [36]