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And some of these medications, of course, everybody knows gabapentin, pregabalin, but they're actually very exciting if you think about the mechanism of action and why they're helpful, because they actually address all of the four points of where the pain comes from and how the brain gets rewired

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GAPDH is an mRNA-binding protein that regulates mRNA nuclear export [123] and influences mRNA stability and translation [124,125,126,127,128,129]