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It is recommended that the procedure be stopped immediately if there is any evidence of organ toxicity.57, 91, 92 Safety Breaks Breaks of 10–15 minutes should be instituted after each 0.5% of BSA treated, allowing partial elimination of phenol between sessions and the return of the QTc interval to baseline.57, 62, 90 Continuous Cardiac Monitoring Multiparametric monitoring (ECG/BP, HR, and O 2 saturation) should be performed for early detection of arrhythmias or other adverse cardiac events whenever the treated area is greater than 1.5% of BSA or the procedure time is longer than 30 minutes.58, 91, 92 Intravenous Hydration Intravenous hydration before and during the procedure helps minimize renal toxicity and facilitates the excretion of phenol through the urinary system, reducing its systemic concentration

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More anticancer activity and reduced toxicity were demonstrated by this complex