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These chemokines promote the migration and local accumulation of osteoclast precursors, further exacerbating bone resorption and disrupting the osteoblast–osteoclast balance (Siddiqui and Partridge, 2017)

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510 The clinical presentation and prognosis of patients with SARS-CoV-2 infection varies widely, from asymptomatic or febrile symptoms in mild cases to fatal acute respiratory distress syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) in severe cases, 511 primarily driven by dysregulated immune responses