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While our initial dataset focused only on primary tumor burden, future melanoma studies will include testing in additional models, i.e., patient-derived xenograft models with clinically relevant genetic alterations (e.g., BRAF , MEK , and NRAS mutations), metastasis models, and syngeneic models in conjunction with immunotherapy (e.g., anti-PD-1, anti-CTLA-4)
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For a common working concentration of 2.5 mg/mL, add 2 mL of solvent directly to the lyophilized vial and allow it to dissolve gently without vortexing, as aggressive agitation can cause peptide aggregation and loss of bioactivity