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Estrogen modulates the local renin angiotensin system via downregulation of ACE and simultaneous upregulation of ACE2, AT2R and ang (1-7) receptor expression levels [57]
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For example, PD-L1Pep-2 peptide-labeled doxorubicin-loaded liposomes increased the CD8 + T-cell/regulatory T-cell ratio in mouse colon tumor tissues more efficiently than combined treatment with PD-L1Pep-2 peptide and untargeted doxorubicin-loaded liposomes 101
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