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This pathway plays an important role in angiogenesis and tumor growth, with a synergistic action by HGF and VEGF on endothelial cells and also an increasing expression of angiogenic factors mediated by HGF ( Everolimus is an oral mTOR inhibitor, which demonstrated encouraging antitumor activity in a phase II study of previously-treated advanced GEA ( Interestingly, the PARP inhibitor olaparib has shown a significant improvement in OS when added to paclitaxel as second-line therapy in a phase II study enrolling Asian patients with advanced GEA, particularly in the molecular subset with ataxia-telangiectasia mutated protein (ATM)-negative tumors ( Therefore, in the phase III GOLD study Asian patients with advanced GEA progressing after or during first-line chemotherapy were randomized 1:1 to oral olaparib plus paclitaxel or placebo plus paclitaxel