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Molecular Physiology and Pathophysiology of Bilirubin Handling by the Blood, Liver, Intestine, and Brain in the Newborn | Physiological Reviews | American Physiological Society

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Signs of deficiency include: • Fatigue and low energy • Memory issues and brain fog • Numbness or tingling in the hands and feet • Mood swings or depression • Pale skin and shortness of breath Supplementing Safely: Dosage and Absorption Tips While B12 is generally safe as it’s water-soluble (meaning excess is excreted), certain considerations can help you get the most out of your supplement: • Sublingual Supplements : These are absorbed directly into the bloodstream, bypassing the digestive system, making them ideal for those with absorption issues