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REMINDER TO ADJUST DOSING ACCORDING TO LIVER FUNCTION MONITORING (APRIL 2018) l INDICATIONS AND DOSE Inborn errors of primary bile acid synthesis (initiated by a specialist) The MHRA is aware of reports of serious liver injuries and deaths in patients with primary biliary cholangitis with pre-existing moderate or severe liver impairment who were not adequately dose-adjusted

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2007 Jun;97(6):1138-43