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Further studies are needed to clearly understand the biological effects of Se supplementation, considering baseline Se levels, selenoprotein gene polymorphisms, comorbidities, and main clinical outcomes ( Iron and copper Deficiency of Fe and I remains the main health care problem, affecting about 30% of the world’s population ( The bioavailability of Fe controls complex metabolic processes in immune cell homeostasis and inflammation ( in vitro reduces the percentage of M1 cells expressing costimulatory molecules CD86 and MHC-II, prevents lipopolysaccharide-induced pro-inflammatory response by reducing nuclear translocation of NF-κB p65 with reduced expression of, IL-1β, IL-6, IL-12 and TNF-α ( In blood plasma, Cu binds to ceruloplasmin, a transport protein that is a reactive protein of the acute phase

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[Google Scholar] 142.Anderson M.E., Luo J.L