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The relatively common occurrence of excess copper with deficient zinc can thus lead to such diffuse and overlapping symptoms as: fatigue depression anxiety severe PMS learning disabilities headaches impaired memory behavior changes loss of appetite and taste perception slowed sexual maturation sensitive skin hair loss diarrhea delayed wound healing Where Has All The Zinc Gone

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The paracellular and transcellular intestinal permeability can be measured by non-invasive methods in humans [44]