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Soluble Alpha-Klotho exhibits a relatively short systemic half-life in rodent models, typically reported between 2 and 7 hours due to rapid hepatic clearance and endocytic degradation

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In heparin (1000 IU/kg i.p.) pre-treatment studies (2 hours before bleeding initiation), a prominent reduction of the otherwise strongly increased bleeding time was regularly noted in 2-AMP-BPC157 treated animals with either 10 µg or 10 ng/kg b.w., i.p