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1 GPx4 Overview The GPx4 gene is located at the position of sub-band 3 in the main band 13 of the short arm of chromosome 19 in the human genome and the full length of the GPx4 gene is 2865 bases

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An analysis of GST levels in CLL patients showed an elevated expression of GST in individuals responding to chlorambucil and corticosteroids, and this expression was further enhanced in patients who had received multiple rounds of therapy and whose disease was classified as resistant to chlorambucil/steroid treatment (Schisselbauer et al ., 1990)