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The Core Mechanics of Ferroptosis 2.1 Defining ferroptosis: A distinct modality of regulated cell death (RCD) Dixon and his team first outlined the concept of ferroptosis in 2012 [31] and the Nomenclature Committee on Cell Death subsequently gave it an official classification [32]

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The article reviews the roles of selenium and related selenoproteins in immune regulation, analyzes their metabolic processes in solid tumors, and particularly emphasizes the association between GPX4, ferroptosis, and autophagy, offering a theoretical basis for tumor research and treatment