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In an antimicrobial context, this could tentatively be interpreted as ApoE playing a role in coordinating metal ions to alter Aβ aggregation dynamics toward increased cytotoxic aggregate formation to increase Aβ’s antimicrobial efficacy (either alone or in synergy with other AMPs and copper), for which ApoE4 might exert the strongest synergistic AMP effect due to its copper-Aβ interaction and its ability stabilize cytotoxic Aβ oligomers/fibrils (Garai et al., 2014)