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THC and CB1 agonists can reduce the release of presynaptic neurotransmitters and disrupt the long-term plasticity of hippocampal synapses 52,56

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This is documented, not theoretical: see a peer reviewed study in Analytical and Bioanalytical Chemistry establishing a liquid chromatography mass spectrometry method that detects growth hormone releasing peptides and their major urinary metabolites for doping control