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In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism — effects that were abolished in beta‑3 adrenergic receptor (β3-AR) knockout mice, implicating β3-AR signaling as the mechanism of action [1]

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