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To enhance the practical applicability of this framework, future research should also address the heterogeneity in dosing, treatment duration, and patient phenotypes observed across existing studies

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Of these, J-difference editing approaches such as MEGA (MEscher-GArwood) (Mescher et al., 1996) combined with a localization scheme such as PRESS (Point-RESolved Spectroscopy) (Bottomley, 1987), together called MEGA-PRESS, have most commonly been used to measure brain GSH (Dwivedi et al., 2020)