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This may underlie the pathogenesis of several diseases including DM.7 DM has been shown to be associated with male infertility, resulting from changes in sperm quality and testicular tissue damage.2,8 Excessive ROS generated in the testes and epididymides have been found to induce sperm DNA damage in murine models of diabetes.9 Thus, interventions to counteract OS may be of potential therapeutic use for protection against diabetes-associated male infertility